Clavulanate Acid

Clavulanate acid is a beta-lactamase inhibitor that is used in combination with penicillin antibiotics to enhance their efficacy against certain bacterial infections. It works by preventing bacteria from breaking down the penicillin, thus extending its spectrum of activity.

Indications

Bacterial Infections: Often used in combination with amoxicillin or other penicillins to treat various infections including respiratory tract infections, urinary tract infections, skin infections, and others.

Dosage

-Adults: Typically administered as part of a combination therapy with amoxicillin. Dosage depends on the specific formulation and infection type. -Children: Dosage is weight-based and determined by the specific product and infection.

Contra-Indications

-Hypersensitivity: Known hypersensitivity to clavulanate acid or any penicillin antibiotics. -Liver Dysfunction: Use with caution in patients with severe liver dysfunction or history of liver problems related to beta-lactam antibiotics.

Special Precautions

-Liver Function: Monitor liver function periodically during treatment. -Allergic Reactions: Be cautious in patients with a history of allergic reactions to beta-lactam antibiotics. -Renal Impairment: Dosage adjustments may be necessary in patients with significant renal impairment.

Side Effects

-Common: Nausea, diarrhea, rash, and fever. -Serious: Liver dysfunction, jaundice, severe allergic reactions (anaphylaxis), and Clostridium difficile-associated diarrhea.

Drug Interactions

-Probenecid: May increase clavulanate levels. -Anticoagulants: May enhance the effect of anticoagulants like warfarin. -Other Antibiotics: Interaction with other antibiotics can sometimes occur.