Danazol

Danazol is a synthetic steroid derived from ethisterone. It has anti-estrogenic and weak androgenic properties. It is available in capsule form for oral administration.

Indications

-Treatment of endometriosis -Management of fibrocystic breast disease (severe cases) -Prevention of attacks in hereditary angioedema (HAE)

Dosage

-The dosage of danazol varies depending on the condition being treated and should be determined by a healthcare provider. -Typical dosages range from 100 mg to 800 mg per day, divided into two to four doses.

Contra-Indications

-Pregnancy (Category X): Danazol can cause fetal harm and is contraindicated in pregnant women. -Severe hepatic dysfunction -Undiagnosed vaginal bleeding -Porphyria

Special Precautions

-Liver function should be monitored regularly due to potential hepatic effects. -Use with caution in patients with lipid disorders, diabetes mellitus, and migraine.

Side Effects

-Common side effects include weight gain, acne, oily skin, hot flashes. -Androgenic effects such as voice changes, clitoral hypertrophy, and menstrual irregularities may occur. -Rare but serious side effects include liver dysfunction, thromboembolism, and benign intracranial hypertension.

Drug Interactions

-Danazol may interact with oral anticoagulants, cyclosporine, tacrolimus, and insulin, among others. -Dosage adjustments or monitoring may be necessary when used concomitantly with these medications.