Diclofenac

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly used for conditions such as arthritis, muscle pain, and menstrual pain.

Indications

-Osteoarthritis -Rheumatoid arthritis -Ankylosing spondylitis -Acute pain (including postoperative and dental pain) -Dysmenorrhea (painful menstruation) -Migraine attacks

Dosage

-Adults: Typically, 50 mg to 75 mg taken 2-3 times daily, depending on the condition. The maximum daily dose is generally 150 mg. -Children: Dosage should be determined by a healthcare provider based on the child’s weight and the condition being treated.

Contra-Indications

-History of allergic reactions to diclofenac or other NSAIDs -Active or history of peptic ulcer disease or gastrointestinal bleeding -Severe liver or kidney impairment -Severe heart failure -Third trimester of pregnancy

Special Precautions

-Use with caution in patients with a history of gastrointestinal disease, cardiovascular disease, or hypertension. -Monitor for signs of gastrointestinal bleeding or ulceration. -Caution is advised for elderly patients and those with compromised renal function.

Side Effects

-Common: Nausea, diarrhea, constipation, headache, dizziness. -Serious: Gastrointestinal bleeding, liver dysfunction, kidney impairment, cardiovascular events, severe allergic reactions.

Drug Interactions

-May interact with anticoagulants (e.g., warfarin), other NSAIDs, corticosteroids, antihypertensive drugs, and certain antidepressants. -Monitor interactions with blood pressure medications and anticoagulants.