Diclofenac Sodium
-It has a powerful anti-inflammatory action besides its analgesic and antipyretic actions. It is an inhibitor of prostaglandin synthesis. -It is one of a series of phenylacetic acids that have demonstrated anti-inflammatory and analgesic properties. It can also be used in conjunction with other ophthalamic medications such as antibiotics, beta-blockers, carbonic anhydrase inhibitors, cycloplegics and mydriatics.-Rheumatoid arthritis, osteoarthritis, low back pain, ankylosing spondylitis, gout. Acute musculo skeletal disorders, periarthritis (Frozen shoulder) tendinitis, tenosynovitis, bursitis, sprains and dislocations. Painful post-operative conditions. Pain following dental surgery. Painful inflammatory conditions in gynaecology. -Inhibition of intraoperative miosis and postoperative inflammation in cataract surgery.
-100-150 mg daily in 2-3 divided doses. -Maintenance therapy : 50-100 mg in divided doses -Pre-operatively: One drop 4 times at 30 min. intervals during the 2 hrs period prior to surgery. -Post-operatively: One drop 4 times daily upto 2 weeks or as directed by the physician.
-Active or recurrent peptic ulcers, hypersensitivity, asthmatic patients in whom attacks of asthma are precipitated by aspirin or other NSAIDS, pregnancy, lactation. -Soft contact lenses, aspirin/antiinflammatory drug-induced allergy, surgical procedures.
-Patients having a history of G.I. ulceration, haematemesis or melaena, ulcerative colitis, Crohn’s disease, cardiac and renal insufficiency, elderly patients. -Pregnancy, nursing mother, not recommended for children.
-Epigastric pain, nausea, diarrhoea, tiredness, insomnia, skin rash, itching, retention of fluid. -Burning, stinging, delayed healing, GI upset, burning sensation, blurred vision, hypersensitivity, photosensitivity & keratitis punctate.
Increases blood levels of lithium & digoxin. Inhibits diuretics but potentiates potassium sparing diuretics. Methotrexate toxicity enhanced
