Diethylcarbamazine citrate

Diethylcarbamazine citrate is a white to off-white crystalline powder with a bitter taste. It is a derivative of piperazine and is soluble in water. The drug works by immobilizing and killing microfilariae (larval forms) of filarial worms, making it effective against infections like lymphatic filariasis.

Indications

Diethylcarbamazine citrate is indicated for the treatment of: -Lymphatic filariasis (caused by Wuchereria bancrofti, Brugia malayi, or Brugia timori) -Tropical pulmonary eosinophilia -Loiasis (African eye worm infection)

Dosage

The dosage of diethylcarbamazine citrate may vary based on the specific indication and the patient's age and weight. It is typically administered orally, and the exact dosage should be determined by a healthcare professional.

Contra-Indications

Diethylcarbamazine citrate is contraindicated in individuals with a known hypersensitivity to the drug. It should also be avoided in patients with severe renal or hepatic impairment.

Special Precautions

Special precautions should be taken in patients with a history of epilepsy or other seizure disorders. Caution is advised in individuals with cardiovascular diseases, as diethylcarbamazine citrate may cause transient tachycardia.

Side Effects

Common side effects may include nausea, vomiting, dizziness, headache, and malaise. Rare but more serious side effects can include allergic reactions, seizures, and cardiovascular effects such as hypotension and tachycardia.

Drug Interactions

Diethylcarbamazine citrate may interact with other medications, especially those that affect the central nervous system or have cardiovascular effects. It's essential to inform healthcare providers about all the medications, including over-the-counter drugs and herbal supplements, being taken.