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It is naturally occuring organic amine.It is much less potent than Adr. on alpha & beta adrenergic receptors.It additionally acts on dopaminergic(D2) receptors in renal & mesentric blood vessels, dilates them. On heart, it has positive inotropic but little chronotropic effect.I.V. infusion raises cardiac output & systolic BP, little effect on diastolic BP.


Hemodynamic imbalances present in shock syndrome caused by hypovolaemia, myocardial infarction trauma,endotoxins, septicaemia, open heart surgery,acute renal failure& chronic cardiac decompensation in congestive failure.


Adults: 2-50 mcg/kg/min can be increased upto 100 mcg/kg/min by slow i.v. infusion. Children: 2-20 mcg/kg/min.


Pheochromocytoma, uncorrected tachycardia, ventricular fibrillation & hyperthyroidism.

Special Precautions

Dopamine must be diluted. Before IV administration. Hypovolaemia must be corrected before administering Dopamine. Paediatrics: Dose to be reduced. Pregnancy: Use only, if clearly indicated. Lactation: Use only, if clearly indicated. Elderly: Use with caution.

Side Effects

Nausea, vomiting, ectopic beats, tachycardia, anginal pain, palpitation, hypotension, dyspnoea, headache and vasoconstriction

Drug Interactions

Anaesthetics may cause cardiac arrhythmias, MAOIs increases the effect of dopamine.

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