DOPAMINE HCL
It is naturally occuring organic amine.It is much less potent than Adr. on alpha & beta adrenergic receptors.It additionally acts on dopaminergic(D2) receptors in renal & mesentric blood vessels, dilates them. On heart, it has positive inotropic but little chronotropic effect.I.V. infusion raises cardiac output & systolic BP, little effect on diastolic BP.Hemodynamic imbalances present in shock syndrome caused by hypovolaemia, myocardial infarction trauma,endotoxins, septicaemia, open heart surgery,acute renal failure& chronic cardiac decompensation in congestive failure.
Adults: 2-50 mcg/kg/min can be increased upto 100 mcg/kg/min by slow i.v. infusion. Children: 2-20 mcg/kg/min.
Pheochromocytoma, uncorrected tachycardia, ventricular fibrillation & hyperthyroidism.
Dopamine must be diluted. Before IV administration. Hypovolaemia must be corrected before administering Dopamine. Paediatrics: Dose to be reduced. Pregnancy: Use only, if clearly indicated. Lactation: Use only, if clearly indicated. Elderly: Use with caution.
Nausea, vomiting, ectopic beats, tachycardia, anginal pain, palpitation, hypotension, dyspnoea, headache and vasoconstriction
Anaesthetics may cause cardiac arrhythmias, MAOIs increases the effect of dopamine.
