Doxazosin

it is a new quinazoline derivatives with a selective inhibition of the a1 subtype of a adrenergic receptors. The antihypertensive action is produced by a reduction in the smooth muscle tone of peripheral vascular beds leading to a decrease in the total peripheral resistance without significant effects on the cardiac output or heart rate.

Indications

BPH. Hypertension.

Dosage

1 mg once a day. Max. dose: BPH: 8 mg once a day. Hypertension: 16 mg once a day.

Contra-Indications

Hypersensitivity.

Special Precautions

Carcinoma of the prostate which usually co-exists with BPH, should be ruled out before start of doxazosin therapy. Patients advised to avoid driving or performing hazardous tasks. Impaired hepatic function

Side Effects

BPH: Chest pain, fatigue, headache , influenza-like symptoms, pain, hypotension, palpitation, abdominal pain, diarrhoea, nausea, edema, dizziness, dry mouth, somnolence, dyspnea, respiratory disorders, vision abnormalities, impotence, urinary tract infection, increased sweating, anxiety, insomnia. Hypertension: Dizziness, vertigo, postural hypotension, edema, arrhythmia, hypotension, arthralgia/arthritis, muscle weakness, myalgia, kinetic disorders, ataxia, hypertonias, muscle cramps, flushing,

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.