DULOXETINE WITH METHYLCOBALAMIN

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used primarily to treat major depressive disorder, generalized anxiety disorder, and neuropathic pain. Methylcobalamin, a form of vitamin B12, plays a crucial role in nerve function and is often used to treat neurological disorders.

Indications

-Major Depressive Disorder -Generalized Anxiety Disorder -Neuropathic Pain -Diabetic Neuropathy -Vitamin B12 Deficiency

Dosage

Dosage may vary based on the specific condition being treated, patient response, and other factors. Typically, initial doses are lower and gradually increased. Consult a healthcare professional for personalized dosage information.

Contra-Indications

-Hypersensitivity to duloxetine or methylcobalamin -Concomitant use with monoamine oxidase inhibitors (MAOIs) -Severe hepatic impairment -Uncontrolled narrow-angle glaucoma

Special Precautions

-Monitor for suicidal thoughts, especially in the initial treatment phase. -Caution in patients with a history of liver or kidney disease. -Assess for the risk of serotonin syndrome, particularly with concurrent use of other serotonergic drugs. -Regular monitoring of blood pressure is recommended.

Side Effects

-Nausea -Dry mouth -Insomnia -Fatigue -Constipation -Sweating -Increased blood pressure

Drug Interactions

-MAOIs – increased risk of serotonin syndrome -Warfarin – potential for bleeding complications -NSAIDs – increased risk of bleeding -CYP2D6 inhibitors – may increase duloxetine levels -Alcohol – may potentiate central nervous system effects