EDARAVONE

Edaravone is a kind of cerebral protective agent (free radical scavenger). In the early phase of cerebral infarction, N-acetylaspartate (NAA), a neuronal marker, decreases radically. Edaravone was given to patients with acute cerebral infarction, which can inhibit reduction of regional cerebral blood flow around infarction.

Indications

acute cerebral infarction

Dosage

Inj: 30 mg bd

Contra-Indications

Hypersensitivity, severe renal failure

Special Precautions

Dilute with normal saline Pregnancy: contraindicated in women who are or may become pregnant Lactation: Secreted in milk Elderly: Use with caution

Side Effects

Acute renal failure, Abnormal liver functions and icterus accompanied with rise in AST, ALT, ALP, Y-GT and LDH, Thrombocytopenia, Disseminated intravascular coagulation Allergy; main allergic symptoms include tetter, flush, tumefaction, herpes and pruritus. leucocytosis, leukocytopenia, hematocrit drop, hypochromia, thrombocytosis and thrombocytopenia.

Drug Interactions

Cefazolin sodium, piperacillin sodium and cefotetan, with antiepileptic drugs such as diazepam and phenytoin sodium.