Enclomiphene

Enclomiphene is a single isomer of clomiphene citrate. It is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene is a selective estrogen receptor modulator (SERM) that is used for the treatment of certain fertility issues in both men and women. It acts by stimulating the release of hormones necessary for ovulation in women and increasing testosterone production in men.

Indications

-In women: Treatment of ovulatory dysfunction in those trying to conceive. Management of polycystic ovary syndrome (PCOS). In men: Restoration of normal testosterone levels in men with hypogonadism. -Secondary Hypogonadism associated with obesity and metabolic syndrome, male infertility

Dosage

Dosage may vary based on individual patient factors. Consult a healthcare professional for personalized recommendations. Typically, in women: 50 mg once daily for 5 days, starting on the 5th day of the menstrual cycle. In men: Dosage may start at 12.5 to 25 mg daily, with adjustments based on response.

Contra-Indications

-Enclomiphene is contraindicated in individuals with: Known hypersensitivity to the drug. Liver disease. Unexplained uterine bleeding. Ovarian cysts or enlargement not due to polycystic ovary syndrome.

Special Precautions

-Monitor liver function regularly during treatment. -Assess ovarian and uterine conditions in women before therapy initiation. -Use with caution in individuals with a history of thromboembolic disorders. -Caution in males with cardiovascular or cerebrovascular disease. -Monitor the sperm count and gonadotrophin level

Side Effects

Common side effects may include: -Hot flashes. -Headache. -Nausea. -Mood swings. -Visual disturbances. -Abdominal discomfort. -Vomiting, visual disturbance, muscle spasm

Drug Interactions

-Avoid concurrent use with other ovulation-inducing agents. -May interact with certain medications affecting liver function.