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Esomeprazole

Esomeprazole

It works by decreasing the amount of acid produced by the stomach. Esomeprazole is one of the two stereo-enantiomers in omeprazole. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric perietal cell.

Indications

Gastroesophageal reflux disease, Healing and maintenance of healed erosive oesophagitis, Eradication of Helicobacter pylori in combination with appropriate antibacterial regimens.


Dosage

Gastroesophageal reflux disease, healing of erosive esophagitis : 20mg or 40mg once daily for 4 to 8 weeks. Maintenance of healing of erosive esophagitis :20 mg once daily. Symptomatic gastroesophageal reflux : 20mg once daily for 4 weeks. H. pylori eradication to reduce the risk of duodenal ulcer recurrence : Esomeprazole 40mg once daily with amoxicillin 1g twice daily and clarithromycin 500mg twice daily for 10 days


Contra-Indications

Hypersensitivity.


Special Precautions

Nursing mothers, pediatric patients, for patients with severe liver impairment, a dose of 20mg of esomeprazole should not be exceeded, pregnancy.


Side Effects

Headache, diarrhea, abdominal pain, nausea, flatulence, dry mouth constipation, increased creatinine, uric acid, increased or decreased hemoglobin, white blood cell count, platelets, increased bilirubin, alkaline phosphatase, ALT, AST, hypokalemia, hyponatremia, hyperkalemia, hypernatremia, altered thyroid function tests.


Drug Interactions

Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability e.g., ketoconazole, iron salts and digoxin.


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