GLICLAZIDE
It is a anti-diabetic agent with both metabolic and vascular properties. It restores the early peak of insulin secretion and ensures glycaemic control throughout 24 hours without hypoglycaemia. Gliclazide combats microthrombosis by decreasing platelet hyper adhesiveness & hyper aggregation, increasing fibrinolytic activity, normalizing prostaglandin metabolism, scavenging free-radicals.Non-insulin dependent diabetes mellitus; diabetes with or without obesity in adults, diabetes in the elderly, diabetes with vascular complications.
80-320 mg daily. Usually 160 mg daily.
Pregnancy, severe renal or hepatic failure, severe ketosis, acidosis, diabetic precoma and coma.
Diuretics and barbiturates may reduce the drug activity.
Cutaneous reactions, blood dyscrasias.
Hypoglycaemic effect increased by aspirin, phenylbutazone, clofibrate, sulphona-mides, oral anticoagulants and MAOI’s. Hypo-glycaemic effect opposed by rifampicin, barbiturates, alcohol, diuretics, diazoxide, glucocorticoids, oestrogens and sympathomimetic drugs.