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It is active against dermatophytes, including Epidermophyton, Trichophyton, Microsporum etc. but not against Candida and other fungi, causing deep mycoses.


Fungal infections of skin; nails and scalp. Tinea of hands and beard, athlete’s foot.


Adults: 500-1000 mg daily with meals as a single dose or divided doses. Children: 10 mg/kg body wt (125-250 mg) daily in single or divided doses.


Severe liver disease. Porphyria, monilial infection, SLE, hypersensitivity.

Special Precautions

long term use. Paediatrics: Reduced dose necessary. Pregnancy: Safety not established. Lactation: Use with caution. Elderly: Safe.

Side Effects

Drowsiness, headache, gastric distress, urticaria, photosensitivity.

Drug Interactions

Reduces efficacy of oral anticoagulants and failure of contraceptives. Barbiturates reduces its efficiency, may cause headache, dyspnoea, nausea, flushing. Others: alcohol.

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