Inclisiran

Inclisiran is a novel therapeutic agent belonging to the class of small interfering RNA (siRNA) drugs. It functions by specifically targeting and inhibiting the production of PCSK9 (proprotein convertase subtilisin/kexin type 9), a protein involved in regulating cholesterol levels in the body. By reducing PCSK9 levels, inclisiran helps to enhance the clearance of low-density lipoprotein cholesterol (LDL-C) from the bloodstream, thereby lowering LDL-C levels.

Indications

Inclisiran is indicated for the treatment of hypercholesterolemia, particularly in individuals with familial hypercholesterolemia or those at high risk of cardiovascular events due to elevated LDL-C levels despite maximal tolerated lipid-lowering therapy.

Dosage

The recommended dosage of inclisiran is typically administered as a subcutaneous injection. The specific dosage regimen may vary based on individual patient factors and treatment goals. It is usually administered at specified intervals, as determined by the prescribing healthcare provider.

Contra-Indications

Inclisiran is contraindicated in individuals with a history of hypersensitivity or allergic reactions to the drug or any of its components. It is also contraindicated in pregnant or breastfeeding women due to potential risks to the fetus or nursing infant.

Special Precautions

Special precautions should be taken in individuals with hepatic impairment or dysfunction, as inclisiran metabolism primarily occurs in the liver. Close monitoring of liver function tests may be necessary in such patients. Additionally, inclisiran may interact with other medications, so healthcare providers should carefully review a patient's medication profile before initiating treatment.

Side Effects

Common side effects of inclisiran may include injection site reactions (such as pain, redness, or swelling), flu-like symptoms, headache, and back pain. Rare but serious adverse effects may include liver function abnormalities, allergic reactions, or other unexpected reactions. Patients should promptly report any unusual symptoms to their healthcare provider.

Drug Interactions

Inclisiran's metabolism may be affected by concomitant use of certain medications, particularly those that affect liver enzymes or drug transporters. Healthcare providers should review a patient's medication list to identify potential drug interactions before initiating treatment with inclisiran.