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Isosorbide 5 Mononitrate

Isosorbide 5 Mononitrate

It is more active & longer acting than isosorbide dinitrate. It is effective in classical as well as variant angina & increases exercise tolerance, postpones ECG changes of ischaemia.


Pulmonary hypertension, prophylaxis of angina pectoris. Post myocardial infarction therapy, CHF & acute L.V.F. Not recommended for acute attacks of angina.


20 mg. 2-3 times a day.


Hypotension, circulatory failure, pregnancy.

Special Precautions

Start with low dosage & withdraw gradually. Paediatrics: Not recommended. Pregnancy: Caution should be taken. Lactation: Caution should be taken. Elderly: Caution should be taken.

Side Effects

Throbbing headache, flushing, sweating, weakness, palpitation, dizziness.

Drug Interactions

Orthostatic hypotension when combined with calcium channel blockers, antihypertensives, phenothiazines, tricyclic antidepressants. Alcohol may produce severe hyotension & collapse. Increases bioavailability of dihydroergotamine.

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