Isosorbide 5 Mononitrate

It is more active & longer acting than isosorbide dinitrate. It is effective in classical as well as variant angina & increases exercise tolerance, postpones ECG changes of ischaemia.

Indications

Pulmonary hypertension, prophylaxis of angina pectoris. Post myocardial infarction therapy, CHF & acute L.V.F. Not recommended for acute attacks of angina.

Dosage

20 mg. 2-3 times a day.

Contra-Indications

Hypotension, circulatory failure, pregnancy.

Special Precautions

Start with low dosage & withdraw gradually. Paediatrics: Not recommended. Pregnancy: Caution should be taken. Lactation: Caution should be taken. Elderly: Caution should be taken.

Side Effects

Throbbing headache, flushing, sweating, weakness, palpitation, dizziness.

Drug Interactions

Orthostatic hypotension when combined with calcium channel blockers, antihypertensives, phenothiazines, tricyclic antidepressants. Alcohol may produce severe hyotension & collapse. Increases bioavailability of dihydroergotamine.