Itraconazole
It is a synthetic triazole antifungal agent and is closely related to ketoconazole but has fewer adverse effects and a wider spectrum of activity. It is extensively metabolised by the liver, prior to being excreted in the inactive form in urine and bile.Dermatophytoses,onychomycoses, tinea versicolor,cutaneous candidiasis, oropharyngeal candidiasis, vulvodvaginal candidiasis, chronic mucocutaneous candidiasis (CMC), oculomycoses, systemic mycosis.
100-200 mg in single or divided doses.
Hypersensitivity to other azoles.
Hepatic impairment. Paediatrics: Not recommended. Pregnancy: Contraindicated. Lactation: Use with caution.
Nausea, vomiting, rash, pruritus, pedaloedema, depression, dizziness, vertigo, paresthesia, impotence and loss of libido.
Terfenadine,astemizole, cycloserine or digoxine, oral anticoagulants, phenytoin, rifampicin, INH and H-2 antagonists, oral hypoglycaemic agents.
