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Itraconazole

Itraconazole

It is a synthetic triazole antifungal agent and is closely related to ketoconazole but has fewer adverse effects and a wider spectrum of activity. It is extensively metabolised by the liver, prior to being excreted in the inactive form in urine and bile.

Indications

Dermatophytoses,onychomycoses, tinea versicolor,cutaneous candidiasis, oropharyngeal candidiasis, vulvodvaginal candidiasis, chronic mucocutaneous candidiasis (CMC), oculomycoses, systemic mycosis.


Dosage

100-200 mg in single or divided doses.


Contra-Indications

Hypersensitivity to other azoles.


Special Precautions

Hepatic impairment. Paediatrics: Not recommended. Pregnancy: Contraindicated. Lactation: Use with caution.


Side Effects

Nausea, vomiting, rash, pruritus, pedaloedema, depression, dizziness, vertigo, paresthesia, impotence and loss of libido.


Drug Interactions

Terfenadine,astemizole, cycloserine or digoxine, oral anticoagulants, phenytoin, rifampicin, INH and H-2 antagonists, oral hypoglycaemic agents.


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