Lofexidine

Lofexidine is a medication primarily used for the management of symptoms associated with opioid withdrawal. It belongs to the class of drugs known as alpha-2 adrenergic agonists, which work by reducing the activity of certain neurotransmitters in the brain, thereby alleviating withdrawal symptoms.

Indications

Lofexidine is indicated for the treatment of opioid withdrawal symptoms in individuals attempting to discontinue opioid use.

Dosage

The typical starting dosage of lofexidine is 0.4 mg taken orally four times daily. The dosage may be adjusted based on individual response and tolerance, with a maximum daily dose of 2.4 mg.

Contra-Indications

Lofexidine should not be used in individuals with a known hypersensitivity to the drug or any of its components.

Special Precautions

Caution should be exercised when administering lofexidine to individuals with a history of significant cardiovascular disease, as it may cause hypotension. It should also be used with caution in patients with impaired liver or kidney function.

Side Effects

Common side effects of lofexidine may include drowsiness, dizziness, dry mouth, constipation, and fatigue. Less common side effects may include hypotension, bradycardia, and rebound hypertension upon discontinuation.

Drug Interactions

Lofexidine may interact with other medications that affect blood pressure or heart rate, such as beta-blockers, calcium channel blockers, or other centrally acting drugs. Concurrent use with alcohol or CNS depressants may potentiate sedative effects.