Childhood acute leukemia, choreocar-cinoma. Chronic granulocytic leukaemia.
2.5 mg/kg/day, half dose for maintenance.
Renal or hepatic dysfunction. Monitor blood count, hepatic function, uric acid levels. Paediatrics: Reduced dose necessary. Pregnancy: Not usually prescribed. Lactation: The drug passes into breast milk. Elderly: Reduced dosemay be necessary.
Bone marrow depression, nausea, vomiting,Hepatotoxicity, rash, fever, intestinal ulcers, hyperuricaemia.
Allopurinol increases the blood level of mercaptopurine, anticoagulant action of warfarin may be inhibited by mercaptopurine, other myelosuppressive agents potentiate antineoplastic effect.