MESALAZINE

Mesalazine is an anti-inflammatory drug used primarily in the treatment of inflammatory bowel disease (IBD) conditions such as ulcerative colitis and Crohn's disease. It works by reducing inflammation in the intestines.

Indications

-Ulcerative Colitis -Crohn's Disease (in some cases) -Maintenance of remission in IBD

Dosage

-Adult Dosage: Typically, 2.4 to 4.8 grams per day, divided into multiple doses. The exact dosage depends on the severity of the condition and the specific formulation used. -Pediatric Dosage: Dosage for children should be determined by a healthcare provider, typically based on weight and specific condition.

Contra-Indications

-Hypersensitivity to mesalazine or any component of the formulation -Severe renal impairment -Active gastrointestinal bleeding

Special Precautions

-Use with caution in patients with renal or hepatic impairment -Monitor renal function periodically during treatment -Caution in patients with a history of gastrointestinal obstruction or perforation

Side Effects

-Common: Nausea, vomiting, abdominal pain, headache, diarrhea -Serious: Renal impairment, allergic reactions, liver enzyme abnormalities, blood dyscrasias

Drug Interactions

-Potential interactions with anticoagulants and other medications affecting renal function -May affect the absorption of other drugs, such as azathioprine