Neostigmine

They inhibit the cholinesterase enzyme which breaksdown acetylcholine in the synaptic cleft,thus increasing both the amount and duration of action of the transmitter at the receptor sites. ue to this action they help increase neuromuscular transmission which happen to be of great use in myasthenia gravis. Neostigmine is poorly absorbed orally : Oral dose is 20-30 times higher than parenteral dose & do not effectively penetrate cornea or cross blood-brain barrier. It is partially hydrolysed and partially excreted unchanged in urine.

Indications

Myasthenia gravis.

Dosage

15-30 mg daily or as required 1-5 mg i.v. with atropine 0.4-1.25 mg.

Contra-Indications

Urinary blockage. G.I. organic obstruction.

Special Precautions

Cholinergic weakness. Bronchial asthma, cardiac disease, epilepsy. Parkin-sonism. Vagotonia.

Side Effects

Salivation, sweating, copious tracheo-bronchial secretions, miosis, blurring of vision, nausea, breathlessness, colic, involuntary defecation & urination.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use and share it with your doctor and pharmacist.