NIMESULIDE
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic properties. It belongs to the class of selective COX-2 inhibitors. It is a analgesic and antipyretic in action,apart from its anti inflammatory action. Unlike other NSAID'S, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group. It is absorbed rapidly and completely after oral administration. It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation.-Nimesulide is commonly prescribed for the treatment of acute pain, inflammation, and fever associated with various conditions such as musculoskeletal disorders, dental pain, and dysmenorrhea. -Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders, musculoskeletal disorders, low back pain, dysmenorrhoea, gynaecological conditions, thrombophlebitis dental pain and in ENT inflammations. In children:Fever&other sign and in RT Inflammation.
-The dosage of nimesulide varies depending on the specific condition being treated. It is typically administered orally, and the recommended dose should be followed as per the prescribing healthcare professional's instructions. -Adults: 100 mg twice daily, -Children:: 5mg/kg/day in 2 or 3 divided doses.
-Nimesulide is contraindicated in individuals with a history of hypersensitivity or allergic reactions to NSAIDs. It should be avoided in patients with severe hepatic impairment, gastrointestinal bleeding, or active peptic ulcer. -Hypersensitivity, active peptic ulcer disease, hepatic impairment.
-Special precautions should be taken in patients with a history of cardiovascular diseases, renal impairment, and those who are elderly. It is advised to monitor liver function regularly during treatment. Avoid concurrent use with other NSAIDs, and caution is needed in patients with a history of gastrointestinal disorders. -Active peptic ulcer, elderly patients with moderate renal impairment, congestive heart failure or cirrhosis. Paediatrics: Reduced dose is necessary. Pregnancy: Contraindicated. Lactation: Use with caution. Elderly: Use only, if clearly indicated.
-Common side effects of nimesulide include gastrointestinal disturbances such as nausea, dyspepsia, and abdominal pain. Serious adverse effects may include hepatotoxicity, skin reactions, and cardiovascular events. If any unusual symptoms occur, medical attention should be sought promptly. -Epigastric pain, heart burn, nausea, diarrhoea, vomiting, skin rash, pruritus, dizziness, somnolescence, headache.
-Nimesulide may interact with certain medications, including anticoagulants, antiplatelet drugs, diuretics, and other NSAIDs. It is important to inform healthcare providers about all medications being taken to avoid potential interactions. -Displace methotrexate from its binding sites, decrease the plasma level of theophylline, oral bioavailability of frusemide may be reduced, displaced by the concomitant use of fenofibrate, salicylic acid, valproic acid.
