OESTRADIOL VALERATE

Oestradiol Valerate is a form of estrogen, a female sex hormone. It is a prodrug that is metabolized to estradiol, which plays a key role in female reproductive health. It is often used in hormone replacement therapy (HRT) to treat symptoms associated with menopause such as hot flashes and vaginal dryness. It can also be used for other hormonal conditions like hypogonadism and delayed puberty.

Indications

-Hormone Replacement Therapy (HRT): For relief of menopausal symptoms such as hot flashes and vaginal atrophy. -Hypogonadism: To supplement hormone levels in individuals with low estrogen. -Delayed Puberty: For initiation of puberty in girls with delayed onset. -Gender-affirming therapy: In transgender women to aid in the development of female secondary sexual characteristics.

Dosage

-Dosage will vary depending on the indication and the individual patient. -For HRT, doses typically range from 1 to 2 mg daily. -Always follow the doctor's prescription and guidelines for dosage.

Contra-Indications

-Pregnancy or suspected pregnancy -History of hormone-dependent cancer (e.g., breast or endometrial cancer) -Liver disease -Undiagnosed vaginal bleeding -Known or suspected thrombophilic disorders -Allergic to any component of the medication

Special Precautions

-Regular monitoring by a healthcare provider is necessary to ensure safe use. -Patients should report any unusual vaginal bleeding to their doctor. -Use with caution in patients with cardiovascular or thromboembolic risks. -May need adjustment in patients with liver impairment.

Side Effects

Common side effects include: -Nausea and vomiting -Breast tenderness and enlargement -Headache -Weight change -Mood swings Less common but serious side effects may include: -Blood clots -Stroke -Gallbladder disease -Endometrial cancer -Patients should report any severe or unusual side effects to their doctor.

Drug Interactions

-Certain medications, including antibiotics and anticonvulsants, may reduce the effectiveness of oestradiol valerate. -It may interfere with the effectiveness of other medications, such as thyroid hormones and anticoagulants. -Always discuss all medications and supplements with a healthcare provider before starting oestradiol valerate.