OMEPRAZOLE
It is a gastric proton pump inhibitor. Omeprazole is a substituted benzimidazole derivative acts on the final step of acid production &therefore controls intragastric acidity irrespective of stimulus. It markedly inhibits basal & stimulated gastric acid secretion. Thus it is antisecretory drug which is very effective for rapidly healing peptic ulcers & erosive oesophagitis,& for reducing gastric acid hyper-secretion in patients with Zollinger-Ellison syndrome.Duodenal and gastric ulcers, reflux or ulcerative oesophagitis. Zollinger-Ellison syndrome. NSAID-induced ulcers.
Gastric ulcer; 20 mg once daily for 8 wks, in severe cases increase to 40 mg once daily. Reflux oesophagitis; 20 mg once daily for 4wks, Refractory cases 40 mg once daily. Duodenal ulcer; 20 mg once daily for 4 wks. Zollinger Ellison syndrome; 60 mg once daily. Maintenance therapy 20-120 mg adjusted to response, doses over 80 mg daily should be divided in 2 doses.
Hypersensitivity, neonates.
Exclude the presence of gastric malignancy. Impaired renal & hepatic functions. Paediatrics: Not recommended. Pregnancy: Safety not established. Lactatio: Safety not established. Elderly: No special problem.
Skin rash, nausea, headache, diarrhoea, constipation and flatulence. Increased risk of enteric infections due to reduced acid secretion.
Prolongs elimination of diazepam, warfarin, Phenytoin, Aminophylline, Anti trypsin.
