ORNIDAZOLE
It is a 5-nitroimidazole derivative. Its antimicrobial actions are similar to metronidazole and is used similarly in the treatment of susceptible protozoal infections and prophylaxis of anaerobic bacterial infections.Severe intestinal and hepatic amoebiasis, giardiasis, trichomoniasis of urogenital tract, bacterial vaginosis, treatment of susceptible anaerobic infections.
Amoebiasis: Adults:500mg twice a day orally for 5 days. Children: 10-25 mg/kg body weight in two divided doses. Amoebic dysentery: Adults: 1.5 gms orally once a day for 3 days. Children: 40 mg/kg body weight, once a day for 3 days. Giardiasis: Adults: 1.5 g, once daily for 1-2 days. Children: 40mg/kg body weight for 2 days. Trichomoniasis: 1.5 gm once orally or 500mg twice a day for 5 days. Bacterial vaginosis: 3 tablets of 500mg each as a single dose.
Hypersensitivity to ornidazole and other imidazoles.
In patients with ataxia, vertigo and mental confusion, Ornidazole should be given with caution because the drug has been occasionally reported to aggravate neurological complications in patients with central and peripheral nervous system disorders. Pregnancy & Lactation: To be used only if the potential benefits justifies the potential risk to foetus/neonate.
Nausea, pain in the abdomen, vertigo, headache, skin-rash are generally reported.
Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism.
