PHENINDIONE

Phenindione is an anticoagulant medication used to prevent and treat blood clots. It functions by inhibiting the synthesis of vitamin K-dependent clotting factors, thereby reducing blood clotting.

Indications

-Prevention and treatment of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism). -Prophylaxis for patients with a high risk of clot formation.

Dosage

-Initial Dose: Typically, 10-20 mg daily. -Maintenance Dose: Adjusted based on INR (International Normalized Ratio) monitoring. -Regular monitoring is essential for dosage adjustment. -Administration: Oral, usually once daily or as directed by a healthcare provider.

Contra-Indications

-Severe liver or kidney impairment. -Active bleeding disorders or gastrointestinal bleeding. -Pregnancy (unless benefits outweigh risks). -Hypersensitivity to Phenindione.

Special Precautions

-Monitor INR regularly to avoid over-anticoagulation. -Caution in patients with a history of bleeding disorders, hypertension, or recent surgery. -Use with caution in elderly patients due to increased risk of bleeding.

Side Effects

-Common: Nausea, vomiting, abdominal pain. -Serious: Hemorrhage (e.g., gastrointestinal bleeding, intracranial hemorrhage), liver enzyme abnormalities, skin rash.

Drug Interactions

-Increased Bleeding Risk: Anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin). -Reduced Efficacy: Vitamin K-rich foods, certain antibiotics (e.g., rifampin). -Caution Required: Antifungal agents, other medications affecting blood clotting.