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PRIMIDONE

PRIMIDONE

A deoxybarbiturate, converted by liver to phenobarbitone and phenylethyl malonamide (PEMA), having antiepileptic efficacy and side effects are similar to phenobarbitone. However it may succeed in some patients of rand mal and focal epilepsy refractory to other drugs, also effective in some cases of psychomotor epilepsy. It is mainly used as an adjuvant to phenytoin.

Indications

Grandmal and temporal lobe epilepsy.


Dosage

Adults: Initially 125 mg at bed time increasing every 3 days by 125 mg untill 500 mg daily dose is achieved. Increase by 250 mg every 3 days untill response. Children: 10-20 mg/kg/day.


Contra-Indications

Acute intermittant porphyria.


Special Precautions

Renal, hepatic dysfunction, Respiratory disease. Sod. valproae and sulthiame may inhibit the metabolism of primidone. Concurrent admin. of C.N.S. depressants, alcohol. Paediatrics: Reduced dose necessary. Pregnancy: May cause abnormalities in foetus. Lactation: Should not be used. Elderly: Reduced dose necessary.


Side Effects

C.N.S. disturbances, altered alertness, headache, ataxia, visual disturbances, anaemia, leukopenia and lymph node enlargement, neurotoxicity.


Drug Interactions

Reduce the effect ofanticoagulants, corticosteroids and oral contraceptives.


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MYSOLINE NICHOLAS PIRAMAL INDIA
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