PRIMIDONE

A deoxybarbiturate, converted by liver to phenobarbitone and phenylethyl malonamide (PEMA), having antiepileptic efficacy and side effects are similar to phenobarbitone. However it may succeed in some patients of rand mal and focal epilepsy refractory to other drugs, also effective in some cases of psychomotor epilepsy. It is mainly used as an adjuvant to phenytoin.

Indications

Grandmal and temporal lobe epilepsy.

Dosage

Adults: Initially 125 mg at bed time increasing every 3 days by 125 mg untill 500 mg daily dose is achieved. Increase by 250 mg every 3 days untill response. Children: 10-20 mg/kg/day.

Contra-Indications

-Hypersensitivity to Primidone or any component of the formulation. -Porphyria.

Special Precautions

-Liver function should be monitored regularly due to the potential for hepatotoxicity. -Patients should be monitored for signs of suicidal thoughts or behavior, especially when starting treatment or during dose adjustments. -Use with caution in elderly patients and those with impaired renal function.

Side Effects

Common side effects may include drowsiness, dizziness, nausea, vomiting, loss of appetite, and dizziness.

Drug Interactions

Reduce the effect ofanticoagulants, corticosteroids and oral contraceptives.