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Pseudoephedrine Hcl, Chlorpheniramine Maleate, Guaifenesin

Pseudoephedrine Hcl, Chlorpheniramine Maleate, Guaifenesin

Pseudoephedrine HCl is a sympathomimetic amine commonly used as a decongestant. Chlorpheniramine Maleate is an antihistamine used to relieve symptoms of allergies. Guaifenesin is an expectorant that helps loosen mucus and phlegm in the airways.


This combination medication is indicated for the relief of symptoms associated with nasal congestion, allergic rhinitis, and cough with mucus.


The typical adult dosage is one tablet every 4 to 6 hours, not exceeding 4 tablets in 24 hours. Dosage for children should be determined by a healthcare professional.


Contraindications include hypersensitivity to any of the ingredients, severe hypertension, severe coronary artery disease, narrow-angle glaucoma, and urinary retention.

Special Precautions

Patients with conditions such as diabetes, hyperthyroidism, cardiovascular disease, and prostate enlargement should use this medication with caution. Avoid concurrent use with monoamine oxidase inhibitors (MAOIs) and use cautiously in patients with renal or hepatic impairment.

Side Effects

Common side effects may include dizziness, drowsiness, headache, nausea, and dry mouth. Rare but serious side effects may include palpitations, rapid heart rate, and difficulty urinating.

Drug Interactions

Pseudoephedrine may interact with MAOIs, tricyclic antidepressants, and other sympathomimetic agents. Chlorpheniramine may interact with CNS depressants, alcohol, and other anticholinergic drugs. Guaifenesin may interact with medications that suppress cough reflex.

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