Rabeprazole
Rabeprazole is a proton pump inhibitor (PPI) used to reduce stomach acid production. It is commonly prescribed for conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. By inhibiting the proton pump in the stomach lining, Rabeprazole helps to alleviate symptoms and promote healing.-Gastroesophageal reflux disease (GERD) -Peptic ulcers -Zollinger-Ellison syndrome -Helicobacter pylori eradication (in combination with antibiotics)
-For GERD: Typically 20 mg once daily, for up to 4-8 weeks. -For Peptic Ulcers: 20 mg to 40 mg once daily, depending on severity. -For Zollinger-Ellison syndrome: Dosage is individualized based on patient needs and response.
-Hypersensitivity to Rabeprazole or other PPIs -Severe liver impairment (use with caution and dose adjustment may be required) -Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
-Long-term use may lead to vitamin B12 deficiency, bone fractures, and kidney issues. -Monitor liver function periodically in long-term therapy. -Avoid abrupt discontinuation to prevent rebound acid hypersecretion.
-Common: Headache, nausea, vomiting, diarrhea, constipation, abdominal pain. -Rare: Allergic reactions, liver enzyme abnormalities, severe skin reactions, bone fractures.
-May reduce the absorption of drugs that require acidic conditions for absorption (e.g., ketoconazole). -Can interact with warfarin, increasing the risk of bleeding. -Concurrent use with methotrexate may increase methotrexate levels.
