Sitagliptin with Metformin

Sitagliptin with Metformin is a combination medication used in the treatment of type 2 diabetes. It combines two active ingredients, sitagliptin and metformin, to address different aspects of diabetes management.

Indications

This combination is indicated for the management of type 2 diabetes mellitus in adults. It is particularly useful when diet and exercise alone are not sufficient to control blood sugar levels.

Dosage

Dosage may vary based on individual patient needs and response. Typically, the dosage is adjusted to provide optimal glycemic control. It is important to follow the prescribed dosage as directed by the healthcare provider.

Contra-Indications

-Known hypersensitivity to sitagliptin or metformin. -Severe renal impairment or end-stage renal disease. -Acute or chronic metabolic acidosis, including diabetic ketoacidosis.

Special Precautions

-Renal function should be assessed before initiating treatment and periodically thereafter. -Discontinue use in patients with severe renal impairment, acute or chronic metabolic acidosis. -Use with caution in elderly patients, those with hepatic impairment, or undergoing surgery.

Side Effects

Common side effects may include gastrointestinal discomfort, diarrhea, nausea, headache, and hypoglycemia (especially when used with insulin or sulfonylureas). Rare but serious side effects may include lactic acidosis, pancreatitis, and allergic reactions.

Drug Interactions

-Potential interactions with other antidiabetic medications. -Cationic drugs (e.g., amiloride, digoxin, morphine) may interact with metformin. -Enzyme inducers or inhibitors may affect the metabolism of sitagliptin.