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SUGAMMADEX

SUGAMMADEX

Sugammadex is a selective relaxant binding agent used in anesthesia to reverse the effects of neuromuscular blocking agents, specifically rocuronium and vecuronium. It works by encapsulating the neuromuscular blocking agents, allowing for their removal from the body.

Indications

-Reversal of neuromuscular blockade induced by rocuronium and vecuronium during surgery. -It is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults and pediatric patients aged 2 years and older undergoing surgery.


Dosage

-The dosage of sugammadex depends on the depth and duration of neuromuscular blockade and the specific neuromuscular blocking agent used. It is administered intravenously under the supervision of a qualified healthcare professional. -IV; 100mg/ml after dilution in single bolus dose as per weight of patient or indication.


Contra-Indications

Sugammadex is contraindicated in patients with known hypersensitivity to the drug. Special caution is required in patients with severe renal impairment.


Special Precautions

-Monitor renal function in patients with renal impairment. -Caution in patients with known allergies or hypersensitivity reactions. -Use with caution in pregnant or breastfeeding women. Paediatric: Safety and effectiveness in patients younger than 2 years of age have not been established. Pregnancy: Data not sufficient Lactation: Data not sufficient Elderly: This drug is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function.


Side Effects

-Common side effects may include nausea, vomiting, headache, and pain at the injection site. Serious but rare allergic reactions may occur. -Vomiting, pain, nausea, low blood pressure (hypotension), headache, abdominal pain, gas, dry mouth, fever, chills, dizziness, mouth or throat pain, cough, pain in extremities, muscle pain, insomnia, anxiety, reduced sense of touch, restlessness, depression, decreased red blood cell count, high blood pressure (hypertension), itching, skin redness, low blood calcium, heart disorders, or fast or slow heart rate.


Drug Interactions

-Sugammadex may interact with certain medications, including hormonal contraceptives, and may affect their efficacy. Inform the healthcare provider about all medications being taken. -Toremifene, hormonal contraceptives


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