SULTAMICILLIN
Sultamicillin is a prodrug of ampicillin and sulbactam, belonging to the beta-lactam antibiotic class. It combines the bactericidal activity of ampicillin with the beta-lactamase inhibitor sulbactam, enhancing its spectrum of action against a wide range of bacteria.Sultamicillin is primarily prescribed for the treatment of bacterial infections caused by susceptible organisms. It is commonly used for respiratory tract infections, urinary tract infections, skin and soft tissue infections, and genital infections.
Dosage of sultamicillin varies depending on the severity of the infection, patient's age, and renal function. Typically, the recommended dosage for adults is 375-750 mg orally every 12 hours. Dosage adjustments may be necessary in patients with renal impairment.
Sultamicillin is contraindicated in individuals with a known hypersensitivity to penicillins or beta-lactamase inhibitors. It should also be avoided in patients with a history of severe allergic reactions to other beta-lactam antibiotics.
Caution should be exercised when prescribing sultamicillin to patients with a history of allergic reactions, especially those with a predisposition to penicillin allergy. Patients with renal impairment may require dosage adjustments to prevent drug accumulation and toxicity.
Common side effects of sultamicillin include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Allergic reactions ranging from rash to severe anaphylaxis may also occur. Prolonged use may lead to superinfections caused by resistant organisms.
Sultamicillin may interact with other medications, including oral contraceptives, anticoagulants, and probenecid. Concurrent use of sultamicillin with these drugs may result in altered efficacy or increased risk of adverse effects. It is important to consult a healthcare professional before initiating any new medications alongside sultamicillin.
