Telmisartan

It acts by blocking the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis. It has more affinity for AT1 receptor than for AT2 receptor.

Indications

Management of hypertension.

Dosage

40mg once a day. Blood pressure response is dose related over the range of 20-80mg.

Contra-Indications

In patients with biliary obstructive disorders or hepatic insufficiency, pregnancy and lactation.

Special Precautions

Interactions (Appendix 10c).

Side Effects

Upper respiratory tract infection, dizziness, back pain, sinusitis, diarrhoea.

Drug Interactions

Digoxin, warfarin.