Trandolapril

It is the ethyl ester prodrug of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor. The effect of trandolapril in hypertension appears to result primarily from the inhibition of circulating and tissue ACE activity thereby reducing angiotensin II formation, decreasing vasoconstriction, decreasing aldosterone secretion, and increasing plasma renin. Decreased aldosterone secretion leads to diuresis, natriuresis, and a small increase of serum potassium.

Indications

Hypertension.

Dosage

2 to 4mg once daily. Patients inadequately treated with once-daily dosing at 4 mg may be treated with twice-daily.

Contra-Indications

Hypersensitive, patients with a history of angioedema.

Special Precautions

Impaired renal function, Hyperkalemia and potassium-sparing diuretics, cough.

Side Effects

Cough, dizziness, diarrhea, and hypotension. AV first degree block, bradycardia, edema, flushing, hypotension, palpitations, drowsiness, insomnia, paresthesia, vertigo, pruritus, rash, pemphigus, abdominal distention, abdominal pain/cramps, constipation, dyspepsia, diarrhea, vomiting, pancreatitis.

Drug Interactions

Discuss with doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Trandolapril Warnings section above, and any of the following: Lithobid (lithium) Diuretics (water pills) Insulin and other diabetes medicines Nonsteroidal anti-inflammatory drugs (NSAIDS), such as Advil or Motrin (ibuprofen) and Indocin (indomethacin) Nonprescription medicines that contain stimulants (may include diet pil