Trimethoprim with Sulphadiazine

Indications

Renal, urinary and respiratory tract infection. Gonorrhoea, otitis media, skin infections. Osteomyelitis, skin infections, septicaemia. Bacterial diarrhoea.

Dosage

Adults and children above 12 yrs: 1 tab twice daily 6-12 yrs: 1/2 tab twice daily.

Contra-Indications

Hypersensitivity to Sulph- onamides. Pregnancy, lactation, jaundice, blood dyscrasias, renal impairment, neonates.

Special Precautions

Not recommended if creatinine clearance less than 15 ml/min and in elderly patients. Test blood regularly in long term therapy high fluid intake should be maintained. Folate deficiency.

Side Effects

Crystalluria, allergic reactions, nausea, vomiting, diarrhoea.