Atorvastatin
Atorvastatin is a medication belonging to the class of statins, primarily used to lower cholesterol levels in the blood. It works by inhibiting an enzyme in the liver involved in the production of cholesterol. Atorvastatin is available in oral tablet form and is typically prescribed as part of a comprehensive treatment plan to reduce the risk of cardiovascular events such as heart attacks and strokes. Atorvastatin acts by competitively inhibiting 3-hydroxy-3-methyl glutaryl co-enzyme A (HMGCoA) reductase, an enzyme involved in cholesterol synthesis.Primary hypercholesterolaemia, heterozygous familial hypercholesterolaemia, homozygous familial hypercholesterolaemia or combined hyperlipidaemia.
-The dosage of atorvastatin varies depending on the individual's lipid profile and overall health status. Typically, the starting dose is 10 to 20 mg once daily, with adjustments made based on the patient's response and tolerance. Higher doses may be necessary for those with severe hypercholesterolemia. It is usually taken orally with or without food, preferably in the evening. -Initially :10mg daily. May be increased upto 80mg once daily.
Atorvastatin is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also be avoided in patients with active liver disease or unexplained persistent elevations in liver enzymes. Pregnant and breastfeeding women should not use atorvastatin due to potential risks to the fetus or infant.
Patients with history of liver disease or high alcohol intake. Unexplained muscle pain, tenderness or weakness.
GI effects like abdominal pain, nausea and vomiting. Reversible myositis, headache, altered LFTs, insomnia, anorexia, alopecia, impotence, chest pain, hypoglycaemia and hyperglycaemia.
Antacids, colestipol, digoxin, erythromycin.
