Miltefosine

Indications

Visceral leishmaniasis caused by Leishmania donovani, Cutaneous leishmaniasis caused by Leishmania braziliensis, Leishmania guyanensis, and Leishmania panamensis, Mucosal leishmaniasis caused by Leishmania braziliensis.

Dosage

Oral; 50 mg twice or thrice daily with meals

Contra-Indications

Hypersensitivity, sjogren syndrome

Special Precautions

Paediatric: Safety and efficacy not yet established Pregnancy: Category D Lactation: Not to breast feed during and for 5 months after the treatment Elderly: Monitor renal function

Side Effects

diarrhea, vomiting, asthenia, decreased appetite, pruritis,headache, pyrexia, abdominal pain,

Drug Interactions

Cytochrome 450metabolised drugs.