Ormeloxifene

It belongs to the new category of agents called as Selective Estrogen Receptor Modulators. It has a weak estrogenic and a potent anti-estrogenic profile. It is expected to exert a contraceptive effect and normalize the bleeding from uterine cavity by regularizing the expression of estrogen receptors on the endometrium. It precents proliferation of endometrium and does not affect the cornification of vaginal and cervial epithelium. Both of these processes are estrogen dependent.

Indications

Dysfunctional uterine bleeding.

Dosage

120 mg twice a week, every Sunday/Wednesday for the first 12 weeks and then 60mg on following Sunday/Wednesday for 12 weeks.

Contra-Indications

Jaundice or several hepatic dysfunctions, polycystic ovarian disease, chronic cervicitis or cervical hyperplasia, history of hypersensitivity to drug, chronic illness like tuberculosis, renal disease, nursing mothers in the first 6 months of the postnatal periods.

Special Precautions

Bi-weekly and weekly dosage schedules have to be observed irrespective of menstrual periods, Ormeloxifene has contraceptive properties, Prolongation of menstrual cycle may be observed in some users.

Side Effects

Nausea, vomiting, headache and in some cases weight gain.