Ramosetron HCL

It is a long acting 5-HT3 receptor antagonist. It improves abnormal bowel movement by inhibiting 5-HT3 receptor selectively. It also improves visceral hypersensitivity.

Indications

Diarrhea - predominant irritable bowel syndrome in male patients.

Dosage

Oral : 5mcg one a day. Maximum daily dose is 10mcg.

Contra-Indications

Not recommended to women because of high incidence of side effects. Hypersensitivity.

Special Precautions

Should not be used in patients with constipation predominant irritable bowel syndrome. Diseases showing similar symptoms as IBS should be excluded prior to inhibition of therapy with ramosetron.

Side Effects

Nausea, Vomiting, Abdominal pain, Hard stool, constipation, bloating, reflux esophagitis, duodenal ulcer, palpitation, hepatic dysfunction, proteinurea, thrombocytopenia, leukocytosis.

Drug Interactions

CYP1A2 drugs, Tricyclic antidepressants, phenothiazine antipsychotics, anticholinergics MAO inhibitors opiod agents.