Terlipressin

Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension. It is a prodrug, which is converted to (Lys8)-vasopressin after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound, Produces mesenteric vasoconstriction and thus decreases portal venous inflow and pressure

Indications

Vericeal haemorrhage, Hepatorenal syndrome, Shock

Dosage

Varical Haemorrhage: 2mg as IV followed by 1 or 2mg every 4 to 6hr. if necessary until bleeding is controlled for upto 72hr. Hepatorenal Syndrome: 1-3mg/day for 7-15days. Shock: IV bolus of 1 to 2mg

Contra-Indications

Hypersensitivity to Terlipressin

Special Precautions

Since Glypressin has antidiuretic and pressor activity it should be used with great caution in patients with hypertension, atherosclerosis, cardiac dysrhythmias or coronary insufficiency. Constant monitoring of blood pressure, serum sodium and potassium and fluid balance is essential. Not recommended in Pregnancy & lactation

Side Effects

Abdominal cramps, chest pain, abnormal heart rhythm, nausea, headache, transient blanching and increased arterial pressure.

Drug Interactions

Increases the hypotensive effect of non-selective ?-blockers. Concomitant use of drugs known to induce bradycardia (e.g. propofol, sufentanil) may lower heart rate and cardiac output.