TESTOSTERONE
It is secretd by the interstitial (Leydig) cells of the testes under the influence of LH from pituitary. FSH is mainly responsible for promotion of spermatogenesis in tubular cells. Testosterone is responsible for all the changes that occur in a body at puberty.It is needed for normal spermatogenesis and maturation of spermatozoa & promotes muscle building specially if aided by exercise.Testicular failure : Hypogonadal disorders, eunuchiodism, hypopituitarism, endocrine impotence, loss of libido, delayed puberty, climacteric symptoms. Carcinoma of breast. Osteoporosis, infertility due to disorders of spermatogenesis. Hereditary angioneurotic oedema. Females : Genital carcinoma, endometriosis, fibroids. Breast carcinoma. Menopausal syndrome.
Prostate and male breast carcinoma. Liver and kidney disease. Pregnancy (Maculinization of female foetus).
Prolonged admin. to children (shortening of stature). Hypertension. Myocardial dysfunction. Nephrotic syndrome.
Virilization & menstrual irregularities, Acne, frequent painful penile errections. Oligozoo-spermia. Precocious puberty, oedema,cholestatic jaundice. Hepatic carcinoma. Gynaecomastia.
Poentiates anticoagulants,oral hypoglycaemic agents. Rifampicin, phenobarb may increase rate of metabolism.
