Tromethamine

Tromethamine, also known as Tris or THAM, is an organic amine buffer often used in pharmaceuticals as an alkalizing agent.

Indications

Tromethamine is used primarily to treat metabolic acidosis, including that caused by lactic acidosis or diabetic ketoacidosis. It may also be used in some formulations as a stabilizer or pH adjuster.

Dosage

Dosage of Tromethamine varies depending on the specific formulation and the severity of acidosis. It is typically administered intravenously under medical supervision.

Contra-Indications

Tromethamine is contraindicated in patients with known hypersensitivity to the drug.

Special Precautions

Caution should be exercised in patients with impaired renal function, as Tromethamine is excreted via the kidneys.

Side Effects

Common side effects may include nausea, vomiting, and headache. Rare but serious side effects include allergic reactions.

Drug Interactions

Tromethamine may interact with certain medications, especially those affecting electrolyte balance or renal function. Consultation with a healthcare provider is advised.