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Piperacillin with Tazobactam

Piperacillin with Tazobactam

Piperacillin with Tazobactam is a combination antibiotic that includes Piperacillin, an extended-spectrum penicillin, and Tazobactam, a beta-lactamase inhibitor. This combination is effective against a wide range of bacterial infections, particularly those caused by organisms producing beta-lactamase enzymes. Piperacillin with tazobactam is used to treat a wide variety of bacterial infections. It is a penicillin antibiotic. It works by stopping the growth of bacteria.

Indications

-Intra-Abdominal Infections: Used for treating infections within the abdominal cavity. -Lower Respiratory Tract Infections: Effective against pneumonia and other respiratory infections. -Skin and Soft Tissue Infections: Treats infections involving the skin and underlying tissues. -Urinary Tract Infections: Used for complicated urinary tract infections. -In moderate to sereve infections caused by piperacillin resistant, piperacillin/tazobactam suspectible, beta lactamase producing strains, in appendicitis, peritonitis, skin/soft tissue infection, lower respiratory tract infections, infection in neutropenic patients, intra abdominal infection and UTI.


Dosage

-Dosage is determined based on the specific infection, patient factors, and susceptibility of the causative bacteria. Piperacillin with Tazobactam is typically administered intravenously. -IV infusion over 30 min. The usual total daily dose for adults is 12/1.5g 7 to 10 days given 4.5g every 8 hrs


Contra-Indications

-Hypersensitivity: Avoid in patients with known hypersensitivity to piperacillin, tazobactam, or other beta-lactam antibiotics. -History of Severe Allergic Reactions: Caution in patients with a history of severe allergic reactions to penicillins or other beta-lactam antibiotics.


Special Precautions

-Renal Impairment: Adjustments in dosage may be necessary in patients with renal dysfunction. -Hematologic Monitoring: Regular monitoring of blood counts is recommended during prolonged therapy. -Clostridium difficile-associated Diarrhea: Antibiotic-associated diarrhea, including C. difficile-associated diarrhea, may occur; evaluate if diarrhea persists. -Before using piperacillin/tazobactam, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.


Side Effects

-Common side effects may include nausea, diarrhea, and injection site reactions. Serious side effects are rare but may include allergic reactions, superinfections, and changes in blood clotting parameters. -Nausea, constipation, diarrhea, headache, or trouble sleeping may occur.


Drug Interactions

-Aminoglycosides: Enhanced antibacterial effect when used concomitantly. -Probenecid: May increase and prolong the therapeutic levels of piperacillin. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.


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